Preheat oven to 450 ̊F and line a large, rimmed baking sheet with parchment paper.
Add cauliflower florets, olive oil, minced garlic, and crushed red pepper flakes to a large bowl and toss to coat. Season with salt and pepper, to taste.
Spread seasoned cauliflower on prepared baking sheet in a single layer. Roast for 20-25 minutes at 450 ̊F, stirring once to ensure cauliflower cooks evenly.
Remove from oven and set the broiler to high. Evenly sprinkle cauliflower with ¼ cup freshly grated Parmesan cheese and place under the broiler until golden brown (approximately 2 minutes).
Remove from oven and sprinkle with remaining Parmesan cheese and serve immediately.